Gastrointestinal Retention System (GIRES™)

GIRES™, a gastro-retentive technology, is targeted at therapeutics that:

• have short half-lives
• exhibit a narrow absorption window
• require good pharmacokinetic control due to a narrow therapeutic index
• require extended local delivery to the gastrointestinal tract

These drugs often require frequent dosing or produce unwanted side effects due to widely fluctuating blood drug levels. GIRES™ addresses each of these issues.

GIRES™ technology consists of a controlled–release dosage form inside an inflatable pouch, which is placed in a drug capsule for oral administration. Upon dissolution of the capsule, a gas-generating system inflates the pouch in the stomach. In clinical trials the pouch has been shown to be retained in the stomach for 16-24 hours.

In addition the presence of food enhances the retention of the GIRES™ system.

The GIRES™ system has been tested clinically for performance as well as safety.