Gastrointestinal Permeation
Enhancement Technology (GIPET™)
The development of oral products for poorly permeable therapeutics remains a major challenge within the pharmaceutical industry. Numerous drugs and novel biotechnology products, are administered parenterally (by injection) due to their poor ability to traverse the intestinal membrane. Merrion's GIPET™ technology is a platform technology developed to allow the oral delivery of many poorly permeable compounds, with resultant improvements in patient compliance, safety and efficacy.
The GIPET™ technology platform is clinically proven. In all more than 20 different drugs, including peptide-based drugs, other macromolecules and small organic molecule drugs, have shown substantial improvement in oral bioavailability. Merrion's model allows rapid and low cost screening of several GIPET™ formulations to select the optimal form for further development.
The leading GIPET™ enhancer matrices enjoy food additive status (GRAS) and are normal dietary components with long records of safe use. Clinical safety data for GIPET™ show no treatment-related adverse events were recorded and all GIPET™ treatments were well tolerated.
There are three forms of GIPET™ technology in the Merrion portfolio, which allow Merrion to work with a broad range of drugs with different physiochemical properties. Importantly, GIPET™ formulations involve no chemical modification of the active ingredient.
These key differentiating factors facilitate a rapid, low risk, low cost route to market for new GIPET™ products.
